Agenda

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Day 2 - 1st May

 
Parallel sessions
09:20 - 11:00

7) Young Investigator Session
Assembly Room
Chair – Professor Jeremy Cheadle (Non-Clinical Professor of Medical Genetics, Department of Medical Genetics, Cardiff University)
Co-chair – Professor Trevor Dale (Cardiff School of Biosciences, Cardiff University)

Panel: Dr Andy Tee (Institute of Medical Genetics, Cardiff University)
Dr Richard Darley (Department of Haematology, Cardiff University)

This session will highlight some of the most significant cancer research undertaken by junior investigators (Ph.D. students, post-doctoral scientists, M.D. students, nurses and other researchers) within Wales.

09:20 - Introduction to the session
Professor Jeremy Cheadle (Non-Clinical Professor of Medical Genetics, Department of Medical Genetics, Cardiff University)
09:30 - P052 - High resolution array-CGH profiling of DNA copy number in malignant peripheral nerve sheath tumours (MPNSTs)
Kiran Mantripragada (Institute of Medical Genetics, Cardiff University)
09:45 - P031 - The role of reactive oxygen species in Ras-mediated Leukaemogenesis
Paul Hole (School of Medicine, Cardiff University)
10:00 - P040 - Defects in cell polarity underlie tuberous sclerosis-associated renal cell carcinoma
Cleo Bonnet (Institute of Medical Genetics, Cardiff University)
10:15 - P049 - Pten deficiency, tumourigenesis and control of the intestinal stem cell niche
Victoria Marsh (School of Biosciences, Cardiff University)
10:30 - P034 - Targeting NF-kB, a marker of disease progression, for the treatment of chronic lymphocytic leukaemia
Saman Hewamana (School of Medicine, Cardiff University)
10:45 - P054 - Clinical response of angiomyolipomas in patients with tuberous sclerosis or sporadic LAM to mTOR inhibition
Mark Davies (Institute of Medical Genetics, Cardiff University)
09:00 - 11:00

8) Cancer Immunology
Syndicate Room C
Chair – Dr Awen Gallimore (MRC Senior Research Fellow, Medical Biochemistry and Immunology, Cardiff University)
Co-chair – Dr Andy Godkin (Clinical Reader in Gastroenterology, Infectious Diseases, Respiratory Medicine and Gastroenterology, University Hospital Wales)
09:00 - S021 - Prostate cancer vaccines
Professor Hardev Pandha (Professor of Medical Oncology, Department of Oncology, Postgraduate Medical School, University of Surrey)
09:30 - S022 - The functional plasticity of human gamma/delta T cells and their exploitation in cancer therapy
Dr Matthias Eberl (RCUK Fellow, Medical Biochemistry and Immunology, School of Medicine, Cardiff University)
10:00 - S023 - Immunomodulatory effects of localised radiation therapy in cancer: implications for multimodal therapies
Dr Zsuzsanna Tabi (Senior Lecturer, Department of Oncology, School of Medicine, Cardiff University)
10:30 - P015 - 5T4 as a Tumour Associated Antigen in Malignant Pleural Mesothelioma
Dr Saly El-Taei (Post-doctoral Research Fellow, Department of Oncology, School of Medicine, Cardiff University)
10:45 - P053 - The role of CD4+FOXP3+ regulatory T cells in patients with colorectal cancer
Garreth Betts (Medical Biochemistry and Immunology, Cardiff University)
09:00 - 11:00

9) "Do dogs give you cancer?" - risk, prevention and perceptions of cancer
Organised by the Wales Cancer Alliance
Syndicate Room D
Chair - Dr Ian Lewis (Scientific Director, Tenovus)
Co-chair – Karen Robinson (Assistant Director of Services for Wales Central and the South West, Breast Cancer Care Cymru)
09:00 - S024 - "Do dogs give you cancer?" - risk, prevention and perceptions of cancer
Dr Ian Lewis (Scientific Director, Tenovus)
09:45 - Communication breast cancer risk
Laura Wilson (Outreach Manager, Breast Cancer Care Cymru)
10:10 - Discussion from the floor
 
10:50 - Close and summary
Karen Robinson (Assistant Director of Services for Wales Central and the south West, Breast Cancer Care Cymru)
09:00 - 11:00

10) Palliative care research: a patient orientated approach
Syndicate Room L
Chair - Dr Anthony Byrne (Medical Director, Marie Curie Cancer Care)
Co-chair - Gareth Griffiths (Scientific Director, Wales Cancer Trials Unit)
09:00 - Chair’s Introduction
Dr Anthony Byrne (Medical Director, Marie Curie Cancer Care)
09:05 - Patient Choice: Developing a focused research portfolio for palliative care
Professor Henry McQuay (Nuffield Professor of Clinical Anaesthetics, Oxford Pain Relief Unit, University of Oxford)
 
09:20 - Patient experience: journeys through supportive and palliative care research
Dr Annmarie Nelson (Marie Curie Palliative Care Senior Research Fellow, Wales Cancer Trial Unit )
Mrs Susan Skyrme (Patient representative)
Mr John Skyrme (Patient representative)
09:35 - S027 - Delivering clear answers to complex problems: good research design
Dr Anthony Byrne (Medical Director, Marie Curie Cancer Care)
09:50 - Questions and Answers
 
10:00 - Delivering research: local study summaries
Dr Anthony Byrne (Medical Director, Marie Curie Cancer Care)
Dr Annmarie Nelson (Marie Curie Palliative Care Senior Research Fellow, Wales Cancer Trials Unit)
Dr Andy Fowell (Macmillan Consultant in Palliative Care, Ysbyty Gwynedd, Bangor)
Dr Richard Hain, (Senior Lecturer in Paediatric Palliative Medicine, Department of Child Health)
10:20 - S028 - Opening the door: how can we improve access to research for patients?
Q and A Session - Open to the Floor
Discussion lead by Barbara Moore (CR UK Senior Research and Information Nurse, Velindre Hospital, Cardiff)
Dr Andy Fowell (Macmillan Consultant in Palliative Care, Ysbyty Gwynedd, Bangor)
11:00 - 11:30

Refreshments - Lower Hall, Marble Hall
Parallel sessions continued
11:30 - 13:30

11) Young investigator session continued
Assembly Room
Chair - Professor Trevor Dale (Cardiff School of Biosciences, Cardiff University)
Co-chair – Professor Jeremy Cheadle (Non-Clinical Professor of Medical Genetics, Department of Medical Genetics, Cardiff University)
Panel - Professor Adrian Harwood (Cardiff School of Biosciences, Cardiff University)
Dr Simon Reed (Department of Pathology, Cardiff University

This session will highlight some of the most significant cancer research undertaken by junior investigators (Ph.D. students, post-doctoral scientists, M.D. students, nurses and other researchers) within Wales.

11:30 - P041 - The APC variant E1317Q predisposes to colorectal tumours by relaxing the target for tumourigenic somatic APC mutations
Duncan Azzopardi (Institute of Medical Genetics, Cardiff University)
11:45 - P032 - RNA interference HTS analysis of the Wnt pathway
Dr Katja Seipel (Cardiff School of Biosciences, Cardiff University)
12:00 - P037 - Using an in vitro mTOR kinase assay to further characterise the mTOR pathway
Dr Elaine Dunlop (Institute of Medical Genetics, Cardiff University)
12:15 - P039 - Anti-estrogens promote an invasive phenotype in intercellular adhesion deficient breast cancer cells
Dr Annabel Borley (Clinical Oncology, Velindre Cancer Centre, Cardiff)
12:30 - P048 – Constitutive expression of proinflammatory cytokines and interferon-stimulated-genes in a model of tumour progression
Kaye Smith (School of Medicine, Cardiff University)
12:45 - P043 - Regulation of immune responses to carcinogen induced tumours
James Hindley (Medical Biochemistry and Immunology, Cardiff University)
11:30 - 13:30

12) Clinical focus – Cancer and primary care
Syndicate Room D
Chair - Professor Claire Wilkinson (Research Director, North Wales Clinical School)
Co-chair - Professor David Weller (Chair of NCRI Primary Care Clinical Studies Group, Professor of General Practice, Division of Community Health Sciences, University of Edinburgh)
11:35 - S029 - Follow up of prostate cancer in primary care
Dr Richard Neal (Clinical Senior Lecturer, Department of General Practice, Cardiff University)
11:55 - S030 - A systematic review of follow-up of cancer in primary care versus secondary care
Dr Ruth Lewis (Lecturer, Department of Primary Care and Public Health, Cardiff University)
12:20 - CR UK HPV core messages project
Professor Claire Wilkinson (Research Director, North Wales Clinical School)
12:45 - S032 - HPV infection in Wales - how big is the problem?
Dr Samantha Hibbitts (HPV Research Team, School of Medicine, cardiff University)
13:00 - S033 - HPV vaccines: 17% and 98% effective – how can they both be correct?
Dr Amanda Tristram (Senior Lecturer - Gynaecological Cancer, Cardiff and The Vale NHS Trust)
13:15 - S034 - Evaluation of HPV vaccination – the next step in Wales
Professor Alison Fiander (Professor of Obstetrics and Gynaecology, School of Medicine, Cardiff University)
11:30 - 13:30

13) “All effective treatment should be free” –a debate
Council Chamber
Chairs - Professor Malcolm Mason (Head of Oncology Section, Department of Oncology and Palliative Medicine, Velindre Hospital, Cardiff)
Gill Donovan (Director of Patient Services, Cancer Care Cymru)
11:35 - Speaking for the motion:
Karen Robinson (Assistant Director of Services for Wales Central and the South West, Breast Cancer Care Cymru)
Professor Richard Sullivan (Department of Social Policy – Health, Population and Society, London School of Economics & Political Science, London)
Professor Gordan McVie (Managing Editor of ecancermedicalscience, Cancer Intelligence, Bristol)
11:55 - Speaking against the motion:
Professor Sir Michael Rawlins (Chairman, National Institute for Health and Clinical Excellence, London)
Dr Fergus Macbeth (Director, National Collaborating Centre for Cancer)
12:10 - Open discussion with contributions from the floor.
 
13:30 - 14:30

Lunch - Lower Hall, Marble Hall
14:30 - 15:40

Plenary session
Assembly Room
Chair - Dr Fergus Macbeth (Director, National Collaborating Centre for Cancer)
Co-chair – Professor David Wynford-Thomas (Dean of Medicine, Cardiff University)
14:30 - S037 - Somatic mutations in human cancer: genome-wide characterisation of structural rearrangements
Dr Andy Futreal (Joint Leader, Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge)
15:00 - The National Institute for Health and Clinical Excellence and its role in cancer care
Professor Sir Michael Rawlins (Chairman, National Institute for Health and Clinical Excellence, London)
15:30
Closing remarks - Assembly Room
Including Prize Presentation - best overall presentation (Young Investigator Sessions)
Professor Tim Maughan (Consultant Clinical Oncologist, Velindre Hospital, Cardiff)
15:40
Close of conference

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